Modeling High Pressure Vapor-liquid Equilibrium of Ternary Systems Containing Supercritical Co2 and Mixed Organic Solvents Using Peng-robinson Equation of State

High pressure vapor-liquid equilibrium (VLE) of CO2-expanded organic solvents is investigated using Peng-Robinson-LCVM-UNIFAC equation of state. Bubble pressure of ten ternary mixtures is predicted using this mixing rule and correlations are developed based only on binary experimental data. Due to the lack of experimental data for liquid phase density in the literature, it was necessary to perform a qualitative assessment of the density based on the bubble pressure behavior described by the equation of state. A sensitivity study of the LCVM parameter numerical value was done considering the coherence of the mixing rule structure and the quality of the simulation. This analysis is useful as a preliminary evaluation to predict the occurrence of liquid-liquid immiscibility and to avoid this region by selecting the appropriate temperature and pressure conditions for supercritical antisolvent micronization techniques. Further research is in progress to measure experimental data of the ternary systems and validate this approach.